SCHEMBL11255993

SCHEMBL11255993

C/C(=N/OCC(=O)Cl)c1ccc(Cl)cc1

nearest known ligand 0.53

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NPC1 O15118 3/20 0.53
RAB9A P51151 3/20 0.53
LMNA P02545 4/20 0.45
CYP1A2 P05177 1/20 0.45
CYP2C9 P11712 1/20 0.45
CYP2C19 P33261 1/20 0.45
SMN1; SMN2 Q16637 3/20 0.45
PTBP1 P26599 1/20 0.45
HPGD P15428 1/20 0.44
MAPT P10636 1/20 0.44
L3MBTL1 Q9Y468 3/20 0.43
MAPK1 P28482 1/20 0.43
HTT P42858 1/20 0.43
POLB P06746 3/20 0.42
KDM4E B2RXH2 1/20 0.41
ALDH1A1 P00352 1/20 0.41
KMT2A Q03164 4/20 0.41
MEN1 O00255 3/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11255995 1.00 NPC1 (0.53) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11247611 0.87 NPC1 (0.57) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL6981882 0.87 NPC1 (0.57) NPC1RAB9ALMNACYP1A2CYP2C9
Hydrochloric Acid SCHEMBL11257015 0.85 NPC1 (0.56) NPC1RAB9ALMNACYP1A2CYP2C9
Hydrochloric Acid SCHEMBL11257017 0.85 NPC1 (0.56) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11406624 0.85 NPC1 (0.52) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11423805 0.84 NPC1 (0.51) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11410650 0.83 RAB9A (0.50) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11417426 0.81 HPGD (0.50) NPC1RAB9ALMNACYP1A2CYP2C9
SCHEMBL11412475 0.78 NPC1 (0.51) NPC1RAB9ALMNACYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4317835-A ANTIINFLAMMATERY, ANALGESIC DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1982-03-02 US disclosed
US-4242348-A ANALGESICS; ANTIIFLAMMATORY AGENTS DUPHAR INTERNATIONAL RESEARCH B.V. (NL) 1980-12-30 US disclosed
US-4044023-A ANTIINFLAMMATORY, ANALGESICS U.S. PHILIPS CORPORATION (US) 1977-08-23 US disclosed