Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | GLS | O94925 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 3/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11257042 | 0.90 | MAPT (0.41) | MAPTNPC1GLSLMNATP53 | |
| SCHEMBL11256038 | 0.88 | MAPT (0.41) | MAPTNPC1GLSLMNATP53 | |
| SCHEMBL11270839 | 0.88 | MAPT (0.45) | MAPTNPC1GLSLMNATP53 | |
| SCHEMBL11257125 | 0.86 | NPC1 (0.44) | MAPTNPC1GLSLMNATP53 | |
| SCHEMBL11265038 | 0.83 | MAPT (0.41) | MAPTNPC1GLSLMNATP53 | |
| SCHEMBL11259929 | 0.83 | MAPT (0.55) | MAPTNPC1GLSLMNAMAPK1 | |
| SCHEMBL11255987 | 0.76 | KMT2A (0.38) | MAPTNPC1LMNATP53MEN1 | |
| SCHEMBL11261115 | 0.76 | MAPT (0.51) | MAPTNPC1LMNATP53MAPK1 | |
| SCHEMBL11259854 | 0.73 | SMN1; SMN2 (0.52) | MAPTNPC1LMNAMEN1KMT2A | |
| SCHEMBL11271738 | 0.73 | MAPT (0.48) | MAPTNPC1LMNATP53MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4344946-A | ANTIARTHRITICS, ANTIRHEUMATICS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-17 | — | — | US | disclosed |