Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 3/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.45 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.45 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CASP3 | P42574 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11263489 | 0.81 | EPHX2 (0.48) | MAPK1CYP1A2CYP3A4CYP2D6CYP2C9 | |
| SCHEMBL3630996 | 0.81 | BRD4 (0.55) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL5565886 | 0.79 | BRD4 (0.50) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL24214429 | 0.79 | MAOB (0.51) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL23603957 | 0.78 | BRD4 (0.49) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL2107054 | 0.77 | NOTUM (0.62) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL2428467 | 0.77 | RAB9A (0.45) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL2109752 | 0.77 | RAB9A (0.45) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL12444310 | 0.77 | BRD4 (0.48) | BRD4RAB9AMAPK1GAACYP1A2 | |
| SCHEMBL4398693 | 0.77 | PTPN1 (0.69) | RAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336264-A | 1-Benzoyl-3-(isoxazolyl or benzisoxazolyl)-ureas and insecticidal use thereof | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |
| US-4322429-A | Isoxazolylbenzamides as insecticides | ELI LILLY AND COMPANY (US) | 1982-03-30 | — | — | US | disclosed |
| EP-0048162-A1 | Isoxazolylbenzamides | ELI LILLY AND COMPANY (US) | 1982-03-24 | — | — | EP | disclosed |
| EP-0042732-A1 | 1-benzoyl-3-substituted ureas and thioureas, their preparation, insecticidal formulations containing them and their use as insecticides | ELI LILLY AND COMPANY (US) | 1981-12-30 | — | — | EP | disclosed |