SCHEMBL11258192

SCHEMBL11258192

CCc1ccc(-n2cc(C#N)c(=O)[nH]c2=O)c(C)c1

nearest known ligand 0.48

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
GAA P10253 2/20 0.48
L3MBTL1 Q9Y468 1/20 0.47
KMT2A Q03164 3/20 0.46
MEN1 O00255 1/20 0.46
SMN1; SMN2 Q16637 2/20 0.41
PDE3B Q13370 2/20 0.37
PDE3A Q14432 2/20 0.37
SRD5A1 P18405 1/20 0.35
KDM4E B2RXH2 2/20 0.35
ALDH1A1 P00352 2/20 0.35
MAPT P10636 1/20 0.35
GALR3 O60755 1/20 0.34
HPGD P15428 1/20 0.34
PRMT5 O14744 1/20 0.33
WDR77 Q9BQA1 1/20 0.33
LMNA P02545 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11250834 0.84 GAA (0.52) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11253313 0.82 GAA (0.50) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11246109 0.82 GAA (0.50) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11247286 0.82 KMT2A (0.51) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11239058 0.80 L3MBTL1 (0.67) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11250334 0.80 GAA (0.51) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11252191 0.80 L3MBTL1 (0.67) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11255788 0.80 L3MBTL1 (0.50) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11247042 0.79 GAA (0.58) GAAL3MBTL1KMT2AMEN1SMN1; SMN2
SCHEMBL11264651 0.78 GAA (0.53) GAAL3MBTL1KMT2AMEN1SMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4338318-A FUNGICIDE OR BACERICIDE TO TREAT PLANT DISEASES WITH A PHENYL URACIL ZOECON CORPORATION (US) 1982-07-06 US disclosed
US-4297297-A α-Cyano-β-(substituted-anilino)-N-ethoxycarbonylacrylamide intermediates ZOECON CORP. (US) 1981-10-27 US disclosed
US-4266056-A FUNGICIDES, BACTERICIDES ZOECON CORPORATION (US) 1981-05-05 US disclosed