Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 2/20 | 0.76 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.64 |
| ▸ | NPC1 | O15118 | 4/20 | 0.64 |
| ▸ | RAB9A | P51151 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.62 |
| ▸ | POLB | P06746 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.59 |
| ▸ | CDK4 | P11802 | 1/20 | 0.58 |
| ▸ | CCND1 | P24385 | 1/20 | 0.58 |
| ▸ | NAMPT | P43490 | 1/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.56 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.52 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.52 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5598218 | 0.88 | HIF1A (0.85) | HIF1ATRPV1NPC1RAB9ALMNA | |
| SCHEMBL8160653 | 0.87 | HIF1A (1.00) | HIF1ATRPV1NPC1RAB9ALMNA | |
| SCHEMBL13947384 | 0.85 | SMN1; SMN2 (0.73) | NPC1RAB9ALMNAPOLBMAPT | |
| SCHEMBL18503580 | 0.83 | HIF1A (0.60) | HIF1ATRPV1NPC1RAB9ALMNA | |
| SCHEMBL1568227 | 0.82 | HIF1A (0.72) | HIF1ATRPV1RAB9AMAPTNAMPT | |
| SCHEMBL14082324 | 0.82 | HIF1A (0.62) | HIF1ATRPV1POLBMAPTNAMPT | |
| SCHEMBL3639491 | 0.82 | HIF1A (0.75) | HIF1ATRPV1MAPTNAMPTSMN1; SMN2 | |
| SCHEMBL10520199 | 0.81 | HIF1A (0.66) | HIF1ATRPV1NPC1RAB9ALMNA | |
| SCHEMBL13988657 | 0.80 | HIF1A (0.64) | HIF1ATRPV1NPC1RAB9AMAPT | |
| SCHEMBL11251889 | 0.79 | SNCA (0.60) | HIF1ANPC1RAB9AMAPTSIRT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |