Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Lithium Ion. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 1/20 | 0.67 |
| ▸ | CA2 | P00918 | 1/20 | 0.67 |
| ▸ | CA5A | P35218 | 1/20 | 0.67 |
| ▸ | CA9 | Q16790 | 1/20 | 0.67 |
| ▸ | LMNA | P02545 | 1/20 | 0.52 |
| ▸ | TSHR | P16473 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | CFTR | P13569 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | ATM | Q13315 | 1/20 | 0.49 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.46 |
| ▸ | F2 | P00734 | 1/20 | 0.45 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28456499 | 0.96 | CA1 (0.67) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL11661242 | 0.83 | CA1 (0.73) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL649457 | 0.81 | CA1 (0.71) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL974358 | 0.81 | CA1 (0.71) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL30100872 | 0.81 | CA1 (0.71) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL3292602 | 0.81 | CA1 (0.71) | CA1CA2CA5ACA9LMNA | |
| Lithium Ion SCHEMBL5013288 | 0.81 | TSHR (0.62) | CA1CA2CA5ACA9LMNA | |
| Lithium Ion SCHEMBL5014281 | 0.81 | CA1 (0.45) | CA1CA2CA5ACA9NPC1 | |
| SCHEMBL9293248 | 0.81 | CA1 (0.53) | CA1CA2CA5ACA9LMNA | |
| SCHEMBL6038746 | 0.80 | CA1 (0.69) | CA1CA2CA5ACA9LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336307-A | MELT SPINNING WITH A ORGANIC ALKALI OR ALKALINE EARTH METAL SULFONATE PORE FORMING AGENT | TEIJIN LIMITED (JP) | 1982-06-22 | — | — | US | disclosed |