SCHEMBL11261573

SCHEMBL11261573

c1ccc(CCC2(Cn3ccnc3)SCCS2)cc1

nearest known ligand 0.77

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.49
POLB P06746 1/20 0.49
CYP3A4 P08684 1/20 0.49
CYP2D6 P10635 1/20 0.49
MAPT P10636 1/20 0.49
CYP19A1 P11511 1/20 0.49
CYP11B1 P15538 1/20 0.49
CYP11B2 P19099 1/20 0.49
TBXAS1 P24557 1/20 0.49
QPCT Q16769 1/20 0.49
CYP4Z1 Q86W10 1/20 0.49
QPCTL Q9NXS2 1/20 0.49
HMOX1 P09601 2/20 0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11264774 0.95 CYP1A2 (0.47) CYP1A2POLBCYP3A4CYP2D6MAPT
SCHEMBL11253361 0.92 CYP1A2 (0.47) CYP1A2POLBCYP3A4CYP2D6MAPT
SCHEMBL11268126 0.88 HMOX1 (0.48) CYP1A2POLBCYP3A4CYP2D6MAPT
SCHEMBL11273068 0.87 CYP1A2 (0.44) CYP1A2POLBCYP3A4CYP2D6MAPT
SCHEMBL11265311 0.87 HMOX1 (0.47) HMOX1
SCHEMBL10247468 0.87 HMOX1 (0.56) CYP19A1CYP11B1CYP11B2HMOX1
SCHEMBL10247104 0.87 CYP19A1 (0.51) CYP19A1CYP11B1CYP11B2HMOX1
SCHEMBL11265300 0.87 HMOX1 (0.62) CYP19A1CYP11B1CYP11B2HMOX1
SCHEMBL11260120 0.86 HMOX1 (0.45) CYP1A2POLBCYP3A4CYP2D6MAPT
SCHEMBL11270193 0.86 CYP11B1 (0.51) CYP1A2POLBCYP3A4CYP2D6MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4359475-A SPERMICIDES, MICROBIOCIDES OR ANTICONVULSANTS SYNTEX (U.S.A.) INC. (US) 1982-11-16 US disclosed