Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 8/20 | 0.49 |
| ▸ | HTR2B | P41595 | 3/20 | 0.49 |
| ▸ | OPRD1 | P41143 | 4/20 | 0.41 |
| ▸ | PNMT | P11086 | 1/20 | 0.37 |
| ▸ | HTR5A | P47898 | 2/20 | 0.34 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | HTR1D | P28221 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | HTR3A | P46098 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 3/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1589928 | 0.86 | HTR2C (0.48) | HTR2CHTR2BOPRD1PNMTHTR2A | |
| Hydrochloric Acid SCHEMBL1591008 | 0.84 | HTR2C (0.47) | HTR2CHTR2BOPRD1PNMTHTR2A | |
| SCHEMBL31515333 | 0.81 | OPRD1 (0.41) | HTR2CHTR2BOPRD1KCNH2HDAC3 | |
| SCHEMBL1590677 | 0.79 | HTR2C (0.45) | HTR2CHTR2BOPRD1HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL3716008 | 0.78 | HTR2C (0.44) | HTR2CHTR2BOPRD1HDAC3HDAC4 | |
| SCHEMBL24408865 | 0.75 | HTR2C (0.35) | HTR2CHTR2BOPRD1HDAC3HDAC4 | |
| Hydrochloric Acid SCHEMBL10502304 | 0.74 | HTR2C (0.49) | HTR2CHTR2BOPRD1PNMTHTR5A | |
| SCHEMBL231585 | 0.73 | OPRD1 (0.49) | HTR2CHTR2BOPRD1HTR2AKCNH2 | |
| SCHEMBL24408860 | 0.72 | HTR2C (0.35) | HTR2CHTR2BHTR2A | |
| Hydrochloric Acid SCHEMBL10502202 | 0.71 | OPRD1 (0.48) | HTR2CHTR2BOPRD1HTR2AKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004952-B1 | SPIRO-(DIHYDROBENZOFURANPIPERIDINES AND -PYRROLIDINES) AND DERIVATIVES THEREOF, METHODS FOR THEIR PREPARATION AND MEDICINES CONTAINING THEM | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-04-07 | — | — | EP | disclosed |
| US-4166119-A | Analgesic and tranquilizing spiro[dihydrobenzofuran]piperidines and pyrrolidines | AMERICAN HOECHST CORPORATION (US) | 1979-08-28 | — | — | US | disclosed |