Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.46 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.46 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | MT-CO2 | P00403 | 1/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.42 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.42 |
| ▸ | MAOA | P21397 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12896270 | 1.00 | CYP19A1 (0.57) | CYP19A1HPGDKMT2APTGS2PTGS1 | |
| SCHEMBL29705753 | 0.82 | ALDH1A1 (0.51) | CYP19A1KMT2APTGS2POLBTSHR | |
| SCHEMBL27540323 | 0.81 | CYP19A1 (0.54) | CYP19A1PTGS2CYP17A1CYP2C19LMNA | |
| SCHEMBL755729 | 0.81 | CYP19A1 (0.54) | CYP19A1HPGDKMT2ACYP17A1POLB | |
| SCHEMBL5537242 | 0.79 | KMT2A (0.67) | HPGDKMT2APTGS2PTGS1POLB | |
| SCHEMBL5544986 | 0.79 | KMT2A (0.67) | HPGDKMT2APTGS2PTGS1POLB | |
| SCHEMBL12896284 | 0.79 | HPGD (0.53) | HPGDKMT2APTGS2PTGS1MT-CO2 | |
| SCHEMBL11130803 | 0.79 | HPGD (0.53) | HPGDKMT2APTGS2PTGS1MT-CO2 | |
| SCHEMBL183940 | 0.79 | KMT2A (0.67) | HPGDKMT2APTGS2PTGS1POLB | |
| SCHEMBL9111312 | 0.79 | CYP19A1 (0.50) | CYP19A1KMT2APTGS2CYP17A1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1027504-C | Process for the preparation of imidazolyl-alkenoic acids | SMITHKLINE BEECHAM CORP (US) | 1995-01-25 | — | — | CN | disclosed |
| CN-1048038-A | IMIDAZOLYL-ALKENOIC ACIDS | SMITHKLINE BEECHAM CORP (US) | 1990-12-26 | — | — | CN | disclosed |
| EP-0060144-A2 | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-09-15 | — | — | EP | disclosed |
| US-4336253-A | Cephalosporin antibiotics | ELI LILLY AND COMPANY (US) | 1982-06-22 | — | — | US | disclosed |