Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE2 | O96020 | 1/20 | 0.55 |
| ▸ | EGFR | P00533 | 1/20 | 0.55 |
| ▸ | CDK1 | P06493 | 1/20 | 0.55 |
| ▸ | CDK4 | P11802 | 1/20 | 0.55 |
| ▸ | SRC | P12931 | 1/20 | 0.55 |
| ▸ | CCND1 | P24385 | 1/20 | 0.55 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.55 |
| ▸ | CDK2 | P24941 | 1/20 | 0.55 |
| ▸ | KDR | P35968 | 1/20 | 0.55 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.55 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.50 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.50 |
| ▸ | TRPV1 | Q8NER1 | 4/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.44 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclohexane SCHEMBL11288085 | 0.97 | CCNE2 (0.53) | CCNE2EGFRCDK1CDK4SRC | |
| SCHEMBL1199478 | 0.83 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30056423 | 0.83 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL9382324 | 0.83 | CHRM1 (0.54) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL9382340 | 0.83 | CHRM1 (0.54) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL7316649 | 0.83 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL7718314 | 0.83 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL30752766 | 0.83 | TRPV1 (0.62) | TRPV1 | |
| SCHEMBL11265240 | 0.83 | GABRA1 (0.52) | GABRA1GABRA5GABRA3GABRA2GABRB2 | |
| SCHEMBL3137800 | 0.83 | GABRA1 (0.72) | GABRA1GABRA5GABRA3GABRA2GABRB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4327026-A | Benzodiazepine derivatives | HOFFMANN-LA ROCHE INC. (US) | 1982-04-27 | — | — | US | disclosed |
| EP-0045452-A2 | Benzodiazepine derivatives, intermediates and their preparation, and pharmaceutical compositions containing them | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1982-02-10 | — | — | EP | disclosed |