Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APEX1 | P27695 | 1/20 | 0.62 |
| ▸ | MAPT | P10636 | 4/20 | 0.62 |
| ▸ | RAB9A | P51151 | 2/20 | 0.62 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 2/20 | 0.56 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.54 |
| ▸ | MGAM | O43451 | 1/20 | 0.53 |
| ▸ | AMY1A | P0DUB6 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | SI | P14410 | 1/20 | 0.53 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.51 |
| ▸ | CTSD | P07339 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 2/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11256989 | 0.85 | APEX1 (0.79) | APEX1RAB9AMEN1KMT2ANPC1 | |
| SCHEMBL11257792 | 0.84 | MEN1 (0.64) | APEX1MAPTMEN1KMT2AGAA | |
| SCHEMBL11481174 | 0.83 | APEX1 (0.60) | APEX1MAPTMEN1KMT2AALDH1A1 | |
| SCHEMBL11272338 | 0.82 | APEX1 (0.68) | APEX1MAPTRAB9AMEN1KMT2A | |
| SCHEMBL11257483 | 0.81 | CTSD (0.55) | APEX1MAPTRAB9AKMT2ANPSR1 | |
| SCHEMBL11808900 | 0.79 | APEX1 (1.00) | APEX1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL18180375 | 0.79 | APEX1 (0.57) | APEX1 | |
| SCHEMBL10487857 | 0.76 | MAPT (0.64) | MAPTMEN1KMT2ARXFP1TDP1 | |
| SCHEMBL5329443 | 0.75 | APEX1 (0.82) | APEX1MEN1KMT2ANPC1ALDH1A1 | |
| SCHEMBL11294710 | 0.74 | APEX1 (0.56) | APEX1MAPTRAB9AMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0019440-B1 | BENZIMIDAZOLONE DERIVATIVES, PROCESS FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PFIZER INC. (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4209527-A | ANTIDIABETIC AGENTS | PFIZER INC. (US) | 1980-06-24 | — | — | US | disclosed |