CTSD — patent landscape

Top predicted compounds (top 20 by supporting neighbours, then confidence)

Compound	Confidence	Supporting neighbours
SCHEMBL309391	1.00	20/20
SCHEMBL309701	0.61	20/20
SCHEMBL309085	0.58	20/20
SCHEMBL309564	0.77	19/20
SCHEMBL309727	0.76	19/20
SCHEMBL309404	0.65	19/20
SCHEMBL309242	0.61	19/20
SCHEMBL167325	0.60	19/20
SCHEMBL256550	0.60	19/20
SCHEMBL308670	0.57	19/20
SCHEMBL163734	0.55	19/20
SCHEMBL163735	0.55	19/20
SCHEMBL166486	0.55	19/20
SCHEMBL175111	0.54	19/20
SCHEMBL175112	0.54	19/20
SCHEMBL166102	0.53	19/20
SCHEMBL166402	0.53	19/20
SCHEMBL166605	0.53	19/20
SCHEMBL166606	0.53	19/20
SCHEMBL255927	0.53	19/20

Clinical trials — most relevant to CTSD by text similarity (a relevance ranking, not an exhaustive list)

Trial	Phase	Status
Efficacy and Safety of Favipiravir and Ribavirin Formulation for Treatment of COVID-19	PHASE2/PHASE3	UNKNOWN
Acid Lipase Replacement Investigating Safety and Efficacy (ARISE) in Participants With Lysosomal Acid Lipase Deficiency	PHASE3	COMPLETED
Single Dosing of Zoledronic Acid in Cancer Therapy Induced Bone Loss (CTIBL)	PHASE3	COMPLETED
Disulfiram in Rheumatoid Arthritis	PHASE2	NOT_YET_RECRUITING
DEFINE - Evaluating Therapies for COVID-19	PHASE1/PHASE2	COMPLETED
The Study of Quadruple Therapy Quercetin, Zinc, Metformin, and EGCG as Adjuvant Therapy for Early, Metastatic Breast Cancer and Triple-negative Breast Cancer, a Novel Mechanism	EARLY_PHASE1	UNKNOWN
Fibroblast Specific Inhibition of LOXL2 and TGFbeta1 Signaling in Patients With Pulmonary Fibrosis.	EARLY_PHASE1	COMPLETED
Respiratory Cathepsins, Proteases Inhibitors and Glycosaminoglycans (GAG) in Mucopolysaccharidosis	nan	COMPLETED
Rab 32 Gene Polymorphisms as a Prognostic Factor in Leprosy Patients	nan	RECRUITING
Salivary Biomarkers for Sjögren's Syndrome Detection	nan	COMPLETED
Diagnostic Value of Serum Cathepsin S and Chromogranin A in DKD	nan	NOT_YET_RECRUITING
Hematological Markers in Idiopathic Carpal Tunnel Syndrome	nan	COMPLETED
Turkish Adaptation of the CTS-6 Evaluation Tool: A Validation and Reliability Study	nan	NOT_YET_RECRUITING
Predicting Pancreatic Necrosis Using mitDNA	nan	UNKNOWN
Multimodal Approach of Electrotherapy Versus Nerve Flossing Technique in Patient With Carpal Tunnel Syndrome	nan	UNKNOWN
Screening of Lysosomal Storage Disorders Diseases in Minority Groups	nan	UNKNOWN
Synovial Fluid Bank From Arthritic Patients	nan	RECRUITING
The Natural History of Alpha-Mannosidosis	nan	COMPLETED
The Role of Vitamin K2 in Preventing Glucocorticoid-Induced Bone Loss in Children With Nephrotic Syndrome	nan	RECRUITING
SRT in Comparison to ERT on Immune Aspects and Bone Involvement in Gaucher Disease	nan	UNKNOWN
An Observational Study of Patients With Lysosomal Acid Lipase Deficiency/Cholesteryl Ester Storage Disease Phenotype	nan	COMPLETED
Role of A Disintegrin and Metalloproteinase (ADAM) in Epithelial Dysfunction	nan	COMPLETED
Effect of Exercise on Ultrasound SWV in CTS Patients	nan	COMPLETED
Acute Pancreatitis Targets (APT) Study	nan	COMPLETED
Chemokine Mechanisms in Chronic Pelvic Pain	nan	COMPLETED
Intraneural Facilitation as a Treatment for Carpal Tunnel Syndrome	nan	COMPLETED
Correlation Between Serum Markers of Unstable Plaque and Virtual Histology of Unstable Plaque Visualized by IVUS	nan	COMPLETED
Influence of Statins in Artery Aneurysms	nan	UNKNOWN
Carpal Tunnel Syndrome: Diagnosis and Treatment Trial	nan	COMPLETED
Diagnosis of Carpal Tunnel Syndrome: Effectiveness of Diagnostic Tests. Clinical Trial of Accuracy	nan	COMPLETED

Related proteins — ESM-2 sequence neighbours (a CTSD binder may also engage these)

Protein	Name	Similarity
Q4LAL9	—	1.000	Q4LAL9 →
P80209	—	0.993	P80209 →
P18242	—	0.992	P18242 →
P24268	—	0.991	P24268 →
Q05744	—	0.991	Q05744 →
Q9DEX3	—	0.991	Q9DEX3 →
O93428	—	0.991	O93428 →
Q21966	—	0.988	Q21966 →
Q9MZS8	—	0.986	Q9MZS8 →
Q9TSZ1	—	0.986	Q9TSZ1 →
P08424	—	0.986	P08424 →
Q03168	—	0.985	Q03168 →
Q9GK11	—	0.985	Q9GK11 →
Q42456	—	0.985	Q42456 →
P60016	—	0.984	P60016 →
Q01294	—	0.983	Q01294 →
P00795	—	0.983	P00795 →
Q6DLS0	—	0.983	Q6DLS0 →
Q9XEC4	—	0.983	Q9XEC4 →
P42210	—	0.982	P42210 →
Q6DYE7	—	0.982	Q6DYE7 →
REN	Renin	0.982	landscape →
Q6DLW5	—	0.981	Q6DLW5 →
P00796	—	0.981	P00796 →
Q8MYN5	—	0.981	Q8MYN5 →
P06281	—	0.981	P06281 →
Q9N2D2	—	0.981	Q9N2D2 →
Q18DC9	—	0.980	Q18DC9 →
P52115	—	0.980	P52115 →
C5FS55	—	0.980	C5FS55 →