Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | DEGS1 | O15121 | 3/20 | 0.41 |
| ▸ | RAB9A | P51151 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 1/20 | 0.35 |
| ▸ | PPARG | P37231 | 1/20 | 0.35 |
| ▸ | PPARA | Q07869 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL466003 | 0.88 | RAB9A (0.46) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL3923056 | 0.79 | RAB9A (0.48) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL11466907 | 0.78 | DEGS1 (0.56) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL3306300 | 0.77 | PTK2 (0.59) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL540536 | 0.75 | NAMPT (0.50) | DEGS1RAB9AMAPT | |
| SCHEMBL16246036 | 0.75 | RAB9A (0.43) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL28322047 | 0.74 | RAB9A (0.50) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL3202851 | 0.73 | RAB9A (0.44) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL3720037 | 0.73 | RAB9A (0.44) | MEN1KMT2ADEGS1RAB9AMAPT | |
| SCHEMBL17675503 | 0.73 | RAB9A (0.44) | MEN1KMT2ADEGS1RAB9AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |