Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CBFB | Q13951 | 2/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.40 |
| ▸ | METAP1 | P53582 | 1/20 | 0.40 |
| ▸ | MDM4 | O15151 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.40 |
| ▸ | ALOX15 | P16050 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.39 |
| ▸ | GPR17 | Q13304 | 1/20 | 0.37 |
| ▸ | MAP2 | P11137 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11266121 | 0.92 | MAP2 (0.46) | MEN1KMT2AMAP2 | |
| SCHEMBL11258473 | 0.88 | CBFB (0.36) | CBFBMEN1KMT2AGPR35MAP2 | |
| SCHEMBL11250335 | 0.85 | MAP2 (0.33) | CBFBTP53MEN1KMT2AGPR35 | |
| SCHEMBL11308976 | 0.84 | MAP2 (0.53) | MDM4TP53MDM2ALOX15MEN1 | |
| SCHEMBL11257258 | 0.84 | CBFB (0.39) | CBFBMETAP2METAP1TP53MEN1 | |
| SCHEMBL11551753 | 0.82 | MAP2 (0.48) | MDM4MDM2ALOX15GPR35GPR17 | |
| SCHEMBL11267254 | 0.82 | METAP2 (0.41) | CBFBMETAP2METAP1MDM4TP53 | |
| SCHEMBL11253133 | 0.81 | CBFB (0.35) | CBFBMETAP2METAP1TP53MEN1 | |
| SCHEMBL11256780 | 0.81 | CBFB (0.34) | CBFBTP53MEN1KMT2AGPR35 | |
| SCHEMBL11262495 | 0.80 | MAP2 (0.34) | CBFBKMT2AMAP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4342769-A | 2-[(Methylsulfinyl)acetyl]-3-heterocyclicindoles and derivatives thereof as immunosuppressants | SCHERING CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| US-4328345-A | Pyridyl substituted indoles | SCHERING CORPORATION (US) | 1982-05-04 | — | — | US | disclosed |
| EP-0010617-B1 | NOVEL 2-SUBSTITUTED-3-HETEROCYCLYLINDOLES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | SCHERING CORPORATION (US) | 1981-08-05 | — | — | EP | disclosed |
| US-4225711-A | Substituted 2-[(methylsulfinyl)acetyl]-3-heterocyclicindoles and their use as immunosuppressants | SCHERING CORPORATION (US) | 1980-09-30 | — | — | US | disclosed |
| EP-0010617-A1 | Novel 2-substituted-3-heterocyclylindoles, their preparation and pharmaceutical compositions containing them | SCHERING CORPORATION (US) | 1980-05-14 | — | — | EP | disclosed |