Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 2/20 | 0.53 |
| ▸ | BCHE | P06276 | 1/20 | 0.53 |
| ▸ | HRH2 | P25021 | 5/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 3/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | SLC22A2 | O15244 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | GLA | P06280 | 1/20 | 0.34 |
| ▸ | ATP4A | P20648 | 1/20 | 0.34 |
| ▸ | APEX1 | P27695 | 1/20 | 0.34 |
| ▸ | PDE4A | P27815 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.34 |
| ▸ | ATP4B | P51164 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10970044 | 0.92 | ACHE (0.50) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10781080 | 0.89 | ACHE (0.48) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10425977 | 0.88 | ACHE (0.49) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10786658 | 0.87 | ACHE (0.47) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10971171 | 0.85 | ACHE (0.45) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10968645 | 0.83 | CYP3A4 (0.44) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL11492218 | 0.82 | ACHE (0.49) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL11492216 | 0.82 | ACHE (0.49) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL11492219 | 0.78 | ACHE (0.50) | ACHEBCHEHRH2CYP3A4CYP2D6 | |
| SCHEMBL10969829 | 0.78 | ACHE (0.56) | ACHEBCHEHRH2CYP3A4CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0049618-A1 | Improvements in or relating to 2,4-disubstituted thiazole derivatives | ELI LILLY AND COMPANY (US) | 1982-04-14 | — | — | EP | disclosed |