Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 6/20 | 0.38 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | RECQL | P46063 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 3/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126886 | 0.91 | FGFR3 (0.46) | FGFR3MEN1KMT2APOLBRECQL | |
| SCHEMBL1126111 | 0.90 | FGFR3 (0.47) | FGFR3MEN1KMT2ALMNAMAPT | |
| SCHEMBL1126214 | 0.87 | MEN1 (0.45) | FGFR3MEN1KMT2APOLBRECQL | |
| SCHEMBL14212787 | 0.79 | FGFR3 (0.41) | FGFR3MEN1KMT2APOLBRECQL | |
| SCHEMBL1126223 | 0.76 | FGFR3 (0.41) | FGFR3 | |
| SCHEMBL1126749 | 0.76 | FGFR3 (0.54) | FGFR3MEN1KMT2APOLBRECQL | |
| SCHEMBL1126237 | 0.75 | FGFR3 (0.56) | FGFR3MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1126407 | 0.73 | FGFR3 (0.59) | FGFR3 | |
| SCHEMBL14212792 | 0.73 | FGFR3 (0.54) | FGFR3MEN1KMT2AKDM4ESMN1; SMN2 | |
| SCHEMBL1126133 | 0.72 | GLO1 (0.49) | MEN1KMT2ALMNAMAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | Novartis AG (CH) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009141386-A1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2009-11-26 | — | — | WO | disclosed |