Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.36 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | TDO2 | P48775 | 1/20 | 0.32 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11262866 | 0.88 | PDE3B (0.38) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL11257186 | 0.84 | PDE3B (0.40) | PDE3BPDE3AKDM4EALDH1A1HPGD | |
| SCHEMBL22114028 | 0.83 | PDE3B (0.45) | PDE3BPDE3AKDM4EALDH1A1TDO2 | |
| SCHEMBL11246499 | 0.83 | TDP1 (0.37) | KDM4E | |
| SCHEMBL11258743 | 0.78 | ALDH1A1 (0.32) | ALDH1A1HPGD | |
| SCHEMBL11257770 | 0.78 | — | — | |
| SCHEMBL21617927 | 0.77 | ALDH1A1 (0.45) | KDM4EALDH1A1HPGD | |
| SCHEMBL11251945 | 0.77 | CYP3A4 (0.31) | ALDH1A1HPGD | |
| SCHEMBL11267998 | 0.77 | ALDH1A1 (0.32) | ALDH1A1HPGD | |
| SCHEMBL31583253 | 0.75 | PLAU (0.46) | PDE3BPDE3AKDM4EALDH1A1TDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4337256-A | ANTIINFLAMMATORY AGENTS; ANTIAGGLOMERANTS; ENZYME INHIBITORS; ANTIULCER AGENTS | TEIKOKU HORMONE MANUFACTURING CO., LTD. (JP) | 1982-06-29 | — | — | US | disclosed |
| EP-0013411-A1 | Isoquinoline derivatives, process for their preparation and pharmaceutical compositions containing them | TEIKOKU HORMONE MFG. CO., LTD. (JP) | 1980-07-23 | — | — | EP | disclosed |