Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | BCHE | P06276 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | AR | P10275 | 1/20 | 0.41 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.38 |
| ▸ | CHKA | P35790 | 1/20 | 0.38 |
| ▸ | EP300 | Q09472 | 1/20 | 0.37 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11251498 | 0.98 | SMN1; SMN2 (0.47) | SMN1; SMN2BCHEALDH1A1ARUSP2 | |
| SCHEMBL11253978 | 0.80 | GAA (0.49) | SMN1; SMN2ALDH1A1ARHTR1AMAPK1 | |
| SCHEMBL11249870 | 0.79 | ALDH1A1 (0.43) | SMN1; SMN2BCHEALDH1A1ARUSP2 | |
| SCHEMBL13949620 | 0.79 | SMN1; SMN2 (0.57) | SMN1; SMN2ALDH1A1HTR1AADRA1AADRA1B | |
| SCHEMBL11480980 | 0.78 | POLB (0.57) | SMN1; SMN2BCHEALDH1A1ARUSP2 | |
| SCHEMBL4998277 | 0.76 | SMN1; SMN2 (0.43) | SMN1; SMN2HTR1AKMT2AADRA1AADRA1B | |
| SCHEMBL11251034 | 0.75 | KMT2A (0.59) | SMN1; SMN2BCHEALDH1A1ARUSP2 | |
| SCHEMBL11266599 | 0.74 | BCHE (0.58) | SMN1; SMN2BCHEALDH1A1ARUSP2 | |
| SCHEMBL4763016 | 0.73 | SMN1; SMN2 (0.46) | SMN1; SMN2HTR1AMEN1KMT2AADRA1A | |
| SCHEMBL2943787 | 0.70 | ALDH1A1 (0.53) | SMN1; SMN2ALDH1A1MAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4309541-A | CHEMICAL INTERMEDIATES TO QUINAZOLINE HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1982-01-05 | — | — | US | disclosed |
| US-4255429-A | HYPOTENSIVE AGENTS | CIBA-GEIGY CORPORATION (US) | 1981-03-10 | — | — | US | disclosed |