Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Nitric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | CYP19A1 | P11511 | 3/20 | 0.45 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.45 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.45 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | USP2 | O75604 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.44 |
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.44 |
| ▸ | HTT | P42858 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.44 |
| ▸ | ALPL | P05186 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Nitric Acid SCHEMBL11272681 | 0.95 | L3MBTL1 (0.49) | L3MBTL1CYP19A1CYP11B1CYP11B2HSP90AA1 | |
| Nitric Acid SCHEMBL11263005 | 0.89 | HSP90AA1 (0.53) | L3MBTL1CYP19A1CYP11B1CYP11B2HSP90AA1 | |
| Nitric Acid SCHEMBL11267648 | 0.89 | HSP90AA1 (0.50) | L3MBTL1CYP19A1CYP11B1CYP11B2HSP90AA1 | |
| Nitric Acid SCHEMBL11258583 | 0.89 | HSP90AA1 (0.48) | CYP19A1CYP11B1CYP11B2HSP90AA1TP53 | |
| Nitric Acid SCHEMBL11268541 | 0.87 | CYP19A1 (0.47) | L3MBTL1CYP19A1CYP11B1CYP11B2HSP90AA1 | |
| SCHEMBL10550847 | 0.87 | CYP11B1 (0.56) | CYP19A1CYP11B1CYP11B2TP53TSHR | |
| Nitric Acid SCHEMBL11267969 | 0.84 | CYP3A4 (0.49) | L3MBTL1CYP19A1CYP11B1CYP11B2HSP90AA1 | |
| Nitric Acid SCHEMBL11264788 | 0.81 | HSP90AA1 (0.54) | CYP19A1CYP11B1CYP11B2HSP90AA1CYP3A4 | |
| SCHEMBL11273426 | 0.81 | CYP11B1 (0.50) | CYP19A1CYP11B1CYP11B2CYP3A4MAPT | |
| SCHEMBL11265341 | 0.81 | CYP11B1 (0.54) | CYP19A1CYP11B1CYP11B2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4358458-A | BACTERICIDE, FUNGICIDES | NORDMARK-WERKE GMBH (DE) | 1982-11-09 | — | — | US | disclosed |