Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN7 | P35236 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | PTPN12 | Q05209 | 1/20 | 0.46 |
| ▸ | PTPN22 | Q9Y2R2 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 8/20 | 0.44 |
| ▸ | PPARA | Q07869 | 5/20 | 0.44 |
| ▸ | PPARD | Q03181 | 3/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | PADI4 | Q9UM07 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | GFER | P55789 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11497969 | 0.93 | PTPN7 (0.50) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11254973 | 0.89 | PPARG (0.46) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11264502 | 0.87 | PPARA (0.44) | PPARGPPARACYP2C19CYP2C9KDM4E | |
| SCHEMBL11254123 | 0.87 | PPARG (0.47) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11257941 | 0.85 | LMNA (0.47) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11252541 | 0.84 | PPARA (0.53) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| Hydrochloric Acid SCHEMBL11259145 | 0.83 | PTPN7 (0.43) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11267392 | 0.81 | PTPN7 (0.46) | PTPN7DUSP3PTPN12PTPN22PPARG | |
| SCHEMBL11290711 | 0.81 | PPARA (0.47) | PPARGPPARACYP2C19CYP2C9KDM4E | |
| SCHEMBL11262582 | 0.77 | PTPN7 (0.44) | PTPN7DUSP3PTPN12PTPN22PPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |