Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 10/20 | 0.71 |
| ▸ | RAB9A | P51151 | 10/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 8/20 | 0.71 |
| ▸ | MAPT | P10636 | 7/20 | 0.71 |
| ▸ | MEN1 | O00255 | 5/20 | 0.71 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.59 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.55 |
| ▸ | NFKB2 | Q00653 | 2/20 | 0.55 |
| ▸ | RELA | Q04206 | 2/20 | 0.55 |
| ▸ | APP | P05067 | 2/20 | 0.54 |
| ▸ | SNCA | P37840 | 1/20 | 0.54 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.52 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.52 |
| ▸ | CASP3 | P42574 | 1/20 | 0.51 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.51 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.51 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.51 |
| ▸ | TP53 | P04637 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1747941 | 0.91 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12593865 | 0.91 | NPC1 (0.60) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL18236210 | 0.90 | NPC1 (0.68) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL27814067 | 0.88 | NPC1 (0.82) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL12428584 | 0.88 | NPC1 (0.57) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL21914837 | 0.86 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL2759505 | 0.85 | MAPT (0.86) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL1821678 | 0.83 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL13151088 | 0.81 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL2115626 | 0.79 | NPC1 (0.65) | NPC1RAB9ASMN1; SMN2MAPTMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0003141-B1 | PROCESS FOR THE PREPARATION OF 2-AMINO-ARYLENOTHIAZOLE COMPOUNDS AND THEIR RING N-SUBSTITUTED DERIVATIVES | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-07-14 | — | — | EP | disclosed |
| US-4252963-A | CYCLIZATION OF PHENYLTHIOUREAS WITH THIONYL CHLORIDE | HOECHST AKTIENGESELLSCHAFT (DE) | 1981-02-24 | — | — | US | disclosed |
| EP-0003141-A2 | Process for the preparation of 2-amino-arylenothiazole compounds and their ring N-substituted derivatives | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-07-25 | — | — | EP | disclosed |