Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 12/20 | 0.65 |
| ▸ | RAB9A | P51151 | 12/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.65 |
| ▸ | MAPT | P10636 | 6/20 | 0.65 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.65 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.65 |
| ▸ | MEN1 | O00255 | 5/20 | 0.65 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.65 |
| ▸ | LMNA | P02545 | 3/20 | 0.65 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.65 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.65 |
| ▸ | GAA | P10253 | 2/20 | 0.65 |
| ▸ | HTT | P42858 | 2/20 | 0.65 |
| ▸ | PKM | P14618 | 1/20 | 0.65 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.65 |
| ▸ | GFER | P55789 | 1/20 | 0.65 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.62 |
| ▸ | IDO1 | P14902 | 2/20 | 0.58 |
| ▸ | TP53 | P04637 | 3/20 | 0.54 |
| ▸ | ACP1 | P24666 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2138878 | 0.86 | IDO1 (0.65) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL13151088 | 0.84 | NPC1 (0.64) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL21914837 | 0.82 | NPC1 (0.62) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL25322650 | 0.81 | SMN1; SMN2 (0.64) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL8019525 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL14184989 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL18058957 | 0.79 | NPC1 (0.59) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL11265618 | 0.79 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2MAPTMEN1 | |
| SCHEMBL13486495 | 0.79 | DYRK1A (0.76) | NPC1RAB9ASMN1; SMN2MAPTKDM4E | |
| SCHEMBL22467930 | 0.79 | DYRK1A (0.67) | NPC1RAB9ASMN1; SMN2MAPTKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-06-23 | — | — | US | claimed |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2012-04-19 | — | — | US | claimed |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | HAARMANN & REIMER GMBH (DE) | 2003-04-17 | — | — | US | claimed |
| US-20020128268-A1 | Use of 2-hydrazino-1,3-thiazoles as antioxidants | HAARMANN & REIMER GMBH (DE) | 2002-09-12 | — | — | US | claimed |
| CN-118702646-A | Novel polymerizable liquid crystal | 罗利克技术有限公司 | 2024-09-27 | — | — | CN | disclosed |
| CN-114026078-B | Novel polymerizable liquid crystal | 罗利克技术有限公司 | 2024-06-07 | — | — | CN | disclosed |
| EP-3990569-A1 | NEW POLYMERIZABLE LIQUID CRYSTAL | Rolic Technologies AG (CH) | 2022-05-04 | — | — | EP | disclosed |
| CN-114026078-A | Novel polymerizable liquid crystal | 罗利克技术有限公司 | 2022-02-08 | — | — | CN | disclosed |
| US-9949970-B2 | Synthesis of new benzothiazole derivatives as potential anti-tubercular agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2018-04-24 | — | — | US | disclosed |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-06-23 | — | — | US | disclosed |
| US-9273039-B2 | Synthesis of new benzothiazole derivatives as potential anti-tubercular agents | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH (IN) | 2016-03-01 | — | — | US | disclosed |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | COUNCIL OF SCIENTIFIC AND INDUSTRIAL RESEARCH | 2012-04-19 | — | — | US | disclosed |
| WO-2008118790-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-10-02 | — | — | WO | disclosed |
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | XENON PHARMACEUTICALS INC. (CA) | 2008-09-25 | — | — | US | disclosed |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | HAARMANN & REIMER GMBH (DE) | 2003-04-17 | — | — | US | disclosed |
| US-4732986-A | Benzothiazole derivatives, processes for their preparation and pharmaceutical compositions containing these compounds | LUDWIG HEUMANN & CO. GMBH (DE) | 1988-03-22 | — | — | US | disclosed |
| EP-0160173-A1 | Benzothiazole derivatives, processes for their production and medicaments containing them | LUDWIG HEUMANN & CO GMBH (DE) | 1985-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20020128268-A1 | Use of 2-hydrazino-1,3-thiazoles as antioxidants | GPX1, LPO, GPX4 | NPC1 1079/4885RAB9A 3084/4885SMN1; SMN2 3373/4885 |
| US-20160175303-A1 | SYNTHESIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, TBCA, SDHA | NPC1 1681/4885RAB9A 2476/4885SMN1; SMN2 4865/4885 |
| US-20120095021-A1 | SYNTHSIS OF NEW BENZOTHIAZOLE DERIVATIVES AS POTENTIAL ANTI-TUBERCULAR AGENTS | TST, SDHB, SDHA | NPC1 2311/4885RAB9A 4194/4885SMN1; SMN2 3952/4885 |
| US-20080234327-A1 | DIHYDROINDAZOLE COMPOUNDS USEFUL IN TREATING IRON DISORDERS | FECH, SLC40A1, HAMP | NPC1 539/4885RAB9A 1254/4885SMN1; SMN2 1839/4885 |
| US-20030072725-A1 | Topical cosmetic agents containing 2-hydrazino-1,3 -heteroazoles | TYR, MITF, HDAC1 | NPC1 2397/4885RAB9A 2330/4885SMN1; SMN2 4816/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.