Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 7/20 | 0.83 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.83 |
| ▸ | SSTR5 | P35346 | 5/20 | 0.65 |
| ▸ | HTR3A | P46098 | 2/20 | 0.55 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | SOS1 | Q07889 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 2/20 | 0.52 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.52 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.52 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.52 |
| ▸ | LMNA | P02545 | 3/20 | 0.50 |
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MLNR | O43193 | 1/20 | 0.50 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.50 |
| ▸ | EED | O75530 | 1/20 | 0.50 |
| ▸ | USP2 | O75604 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL11305424 | 0.99 | KCNH2 (0.81) | KCNH2NR4A2SSTR5HTR3AHKDC1 | |
| Tecastemizole SCHEMBL18200 | 0.91 | KCNH2 (1.00) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| SCHEMBL12657572 | 0.91 | KCNH2 (0.80) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| Tecastemizole SCHEMBL11278980 | 0.90 | KCNH2 (0.98) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| Tecastemizole SCHEMBL9698437 | 0.90 | KCNH2 (0.98) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| Tecastemizole SCHEMBL1652801 | 0.89 | KCNH2 (0.96) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| Bromide SCHEMBL9698163 | 0.88 | KCNH2 (0.69) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| SCHEMBL9699730 | 0.88 | KCNH2 (0.75) | KCNH2NR4A2SSTR5HTR3AL3MBTL1 | |
| Tecastemizole SCHEMBL10510276 | 0.87 | KCNH2 (0.92) | KCNH2NR4A2SSTR5HTR3ASOS1 | |
| SCHEMBL7988153 | 0.86 | KCNH2 (0.70) | KCNH2NR4A2SSTR5HTR3ASOS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101257904-A | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | NYCOMED GMBH (DE) | 2008-09-03 | — | — | CN | claimed |
| CN-101257904-A | Pharmaceutical composition of a pde4 or a pde3/4 inhibitor and a histamine receptor antagonist | NYCOMED GMBH (DE) | 2008-09-03 | — | — | CN | disclosed |
| EP-0005318-B1 | N-HETEROCYCLYL-4-PIPERIDINAMINES, METHODS FOR THEIR PREPARATION, PHARMACEUTICAL COMPOSITIONS COMPRISING THEM, INTERMEDIATES THEREFOR, AND METHOD FOR THE PREPARATION OF THE INTERMEDIATES | JANSSEN PHARMACEUTICA N.V. (BE) | 1982-01-06 | — | — | EP | disclosed |
| US-4219559-A | N-Heterocyclyl-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1980-08-26 | — | — | US | disclosed |
| EP-0005318-A1 | N-Heterocyclyl-4-piperidinamines, methods for their preparation, pharmaceutical compositions comprising them, intermediates therefor, and method for the preparation of the intermediates | JANSSEN PHARMACEUTICA N.V. (BE) | 1979-11-14 | — | — | EP | disclosed |