Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNH2 | Q12809 | 11/20 | 0.75 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.75 |
| ▸ | SSTR5 | P35346 | 3/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.66 |
| ▸ | HRH1 | P35367 | 4/20 | 0.66 |
| ▸ | LMNA | P02545 | 3/20 | 0.66 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.66 |
| ▸ | GAA | P10253 | 2/20 | 0.66 |
| ▸ | EED | O75530 | 2/20 | 0.66 |
| ▸ | HTR3A | P46098 | 2/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.66 |
| ▸ | MEN1 | O00255 | 1/20 | 0.66 |
| ▸ | MLNR | O43193 | 1/20 | 0.66 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.66 |
| ▸ | USP2 | O75604 | 1/20 | 0.66 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.66 |
| ▸ | EGFR | P00533 | 1/20 | 0.66 |
| ▸ | HLA-A | P04439 | 1/20 | 0.66 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.66 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11265895 | 0.88 | KCNH2 (0.83) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Astemizole SCHEMBL8026633 | 0.87 | KCNH2 (0.90) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Bromide SCHEMBL11305424 | 0.87 | KCNH2 (0.81) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| SCHEMBL12657572 | 0.86 | KCNH2 (0.80) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Tecastemizole SCHEMBL18200 | 0.86 | KCNH2 (1.00) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Tecastemizole SCHEMBL9698437 | 0.85 | KCNH2 (0.98) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Tecastemizole SCHEMBL11278980 | 0.85 | KCNH2 (0.98) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Tecastemizole SCHEMBL10510276 | 0.84 | KCNH2 (0.92) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| Tecastemizole SCHEMBL1652801 | 0.84 | KCNH2 (0.96) | KCNH2NR4A2SSTR5CYP2D6HRH1 | |
| SCHEMBL9698288 | 0.84 | KCNH2 (0.70) | KCNH2NR4A2SSTR5CYP2D6HRH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE33833-E | Intermediates for antihistamines, antiserotonine agents | JANSSEN PHARMACEUTICA N.V. (BE) | 1992-02-25 | — | — | US | disclosed |
| US-4820822-A | ANTIHISTAMINE, ANTISEROTONINE AGENTS | JANSSEN PHARMACEUTICA (BE) | 1989-04-11 | — | — | US | disclosed |
| EP-0145037-B1 | N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1989-01-18 | — | — | EP | disclosed |
| US-4760074-A | Novel-N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1988-07-26 | — | — | US | disclosed |
| EP-0099139-B1 | NOVEL N-(BICYCLIC HETEROCYCLYL)-4-PIPERIDINAMINES | JANSSEN PHARMACEUTICA N.V. (BE) | 1987-02-11 | — | — | EP | disclosed |
| US-4634704-A | HISTAMINE AND SEROTONINE ANTAGONISTS | JANSSEN PHARMACEUTICA, N.V. (BE) | 1987-01-06 | — | — | US | disclosed |
| US-4556660-A | ANTIALLERGENS | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-12-03 | — | — | US | disclosed |
| EP-0145037-A2 | N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1985-06-19 | — | — | EP | disclosed |
| EP-0099139-A2 | Novel N-(bicyclic heterocyclyl)-4-piperidinamines | JANSSEN PHARMACEUTICA N.V. (BE) | 1984-01-25 | — | — | EP | disclosed |