Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.43 |
| ▸ | CTSV | O60911 | 3/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | KLK7 | P49862 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272506 | 0.73 | KDM4E (0.42) | LMNAMAPTHPGDKDM4EALDH1A1 | |
| SCHEMBL11253942 | 0.72 | HPGD (0.51) | LMNAMAPTHPGDKDM4EALDH1A1 | |
| SCHEMBL29010555 | 0.71 | HDAC4 (0.50) | HPGDKDM4EALDH1A1KMT2AHDAC4 | |
| SCHEMBL1470672 | 0.71 | ACHE (0.61) | LMNAMAPTMAOBHPGDKDM4E | |
| SCHEMBL29458789 | 0.71 | ACHE (0.61) | LMNAMAPTMAOBHPGDKDM4E | |
| SCHEMBL22004933 | 0.71 | ESR2 (0.67) | LMNAMAPTMAOBHDAC4HDAC2 | |
| SCHEMBL4309836 | 0.69 | ACHE (0.54) | LMNAMAOBHPGDKDM4EALDH1A1 | |
| SCHEMBL23048393 | 0.69 | TP53 (0.53) | LMNAMAPTHPGDKDM4EALDH1A1 | |
| SCHEMBL13959824 | 0.69 | BRAF (0.53) | LMNAHPGDKDM4EALDH1A1KMT2A | |
| SCHEMBL13241186 | 0.69 | ACHE (0.54) | LMNAMAPTMAOBHPGDHDAC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0015523-B1 | INDOLE DERIVATIVES, THEIR PREPARATION AND THEIR USE FOR MEDICAMENTS | Dr. Karl Thomae GmbH (DE) | 1982-10-13 | — | — | EP | disclosed |
| US-4343811-A | ATHEROSCLEROSIS | BOEHRINGER INGELHEIM GMBH (DE) | 1982-08-10 | — | — | US | disclosed |
| EP-0015523-A1 | Indole derivatives, their preparation and their use for medicaments | Dr. Karl Thomae GmbH (DE) | 1980-09-17 | — | — | EP | disclosed |