Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 2/20 | 0.38 |
| ▸ | GRIA4 | P48058 | 4/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 2/20 | 0.33 |
| ▸ | RPA1 | P27694 | 1/20 | 0.33 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.33 |
| ▸ | AR | P10275 | 1/20 | 0.33 |
| ▸ | FABP3 | P05413 | 1/20 | 0.33 |
| ▸ | TACR1 | P25103 | 2/20 | 0.33 |
| ▸ | MYC | P01106 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | CDK8 | P49336 | 1/20 | 0.32 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1081579 | 0.83 | GRIA4 (0.47) | BRD4GRIA4GRIA2CYP1A2LMNA | |
| SCHEMBL1992572 | 0.78 | GRIA4 (0.40) | BRD4GRIA4GRIA2CYP1A2LMNA | |
| SCHEMBL15161901 | 0.78 | BRD4 (0.42) | BRD4CYP1A2KMT2ASMN1; SMN2KDM4E | |
| SCHEMBL1748814 | 0.76 | ALDH1A1 (0.51) | CYP1A2LMNAKMT2ASMN1; SMN2KDM4E | |
| SCHEMBL2637715 | 0.73 | GRIA2 (0.45) | GRIA4GRIA2LMNASMN1; SMN2KDM4E | |
| SCHEMBL1127039 | 0.73 | GRIA4 (0.44) | GRIA4GRIA2LMNAKMT2ASMN1; SMN2 | |
| SCHEMBL2637805 | 0.72 | GRIA4 (0.45) | GRIA4GRIA2KMT2ASMN1; SMN2MCL1 | |
| SCHEMBL1031912 | 0.72 | PHGDH (0.49) | LMNAKDM4E | |
| SCHEMBL1585632 | 0.70 | GRIA4 (0.43) | GRIA4GRIA2CYP1A2KMT2ASMN1; SMN2 | |
| SCHEMBL1081580 | 0.70 | BRD4 (0.39) | BRD4GRIA4GRIA2CYP1A2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2283006-B1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2015-02-25 | — | — | EP | disclosed |
| EP-2626361-B1 | Pyrrole antifungal agents | F2G LTD (GB) | 2014-10-15 | — | — | EP | disclosed |
| EP-2626361-A1 | Pyrrole antifungal agents | F2G Limited (GB) | 2013-08-14 | — | — | EP | disclosed |
| EP-2283006-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G Limited (GB) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009130481-A1 | PYRROLE ANTIFUNGAL AGENTS | F2G LTD (GB) | 2009-10-29 | — | — | WO | disclosed |