Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.42 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.42 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.42 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.36 |
| ▸ | MAOB | P27338 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11267830 | 1.00 | GRM5 (0.44) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11251303 | 0.88 | NPSR1 (0.49) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11251301 | 0.88 | NPSR1 (0.49) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11262129 | 0.86 | GRM5 (0.53) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11262133 | 0.86 | GRM5 (0.53) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11086245 | 0.86 | GRM5 (0.52) | GRM5SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL11086248 | 0.86 | GRM5 (0.52) | GRM5SMN1; SMN2ALDH1A1MAPTKDM4E | |
| SCHEMBL11249640 | 0.81 | GRM5 (0.53) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11249646 | 0.81 | GRM5 (0.53) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA | |
| SCHEMBL11233767 | 0.69 | GRM5 (0.73) | GRM5SMN1; SMN2ALDH1A1MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0011963-B1 | HETEROCYCLIC CARBOXAMIDINE COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1982-07-14 | — | — | EP | disclosed |
| US-4282356-A | HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4250173-A | HYPOGLYCEMIC AGENTS FOR TREATMENT OF DIABETES | BEECHAM GROUP LIMITED (GB) | 1981-02-10 | — | — | US | disclosed |
| EP-0011963-A1 | Heterocyclic carboxamidine compounds, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1980-06-11 | — | — | EP | disclosed |