Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.52 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.50 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | TAS2R38 | P59533 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | RYR2 | Q92736 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11086245 | 1.00 | GRM5 (0.52) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11251303 | 0.87 | NPSR1 (0.49) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11251301 | 0.87 | NPSR1 (0.49) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11267830 | 0.86 | GRM5 (0.44) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11262133 | 0.86 | GRM5 (0.53) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11267827 | 0.86 | GRM5 (0.44) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11262129 | 0.86 | GRM5 (0.53) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 | |
| SCHEMBL11233767 | 0.83 | GRM5 (0.73) | GRM5SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL11233774 | 0.83 | GRM5 (0.73) | GRM5SMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL11253924 | 0.82 | RXFP1 (0.47) | GRM5RXFP1NPSR1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009362-B1 | HETEROCYCLIC DERIVATIVES OF GUANIDINE, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS COMPRISING THEM | McNeilab, Inc. (US) | 1984-06-27 | — | — | EP | disclosed |
| US-4414211-A | HYPOGLYCEMIC/- | MCNEILAB, INC. (US) | 1983-11-08 | — | — | US | disclosed |
| US-4342764-A | Guanidine compounds, pharmaceutical compositions and use | CIBA-GEIGY CORPORATION (US) | 1982-08-03 | — | — | US | disclosed |
| EP-0011963-B1 | HETEROCYCLIC CARBOXAMIDINE COMPOUNDS, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | BEECHAM GROUP PLC (GB) | 1982-07-14 | — | — | EP | disclosed |
| US-4282356-A | HYPOGLYCEMIC | BEECHAM GROUP LIMITED (GB) | 1981-08-04 | — | — | US | disclosed |
| US-4250173-A | HYPOGLYCEMIC AGENTS FOR TREATMENT OF DIABETES | BEECHAM GROUP LIMITED (GB) | 1981-02-10 | — | — | US | disclosed |
| EP-0011963-A1 | Heterocyclic carboxamidine compounds, their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1980-06-11 | — | — | EP | disclosed |
| EP-0009362-A1 | Heterocyclic derivatives of guanidine, their preparation and pharmaceutical formulations comprising them | McNeilab, Inc. (US) | 1980-04-02 | — | — | EP | disclosed |