Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.50 |
| ▸ | MAPT | P10636 | 1/20 | 0.50 |
| ▸ | PDE4A | P27815 | 1/20 | 0.50 |
| ▸ | KDR | P35968 | 1/20 | 0.50 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL8441646 | 1.00 | — | — | |
| Aziridine SCHEMBL7074104 | 0.96 | — | — | |
| Aziridine SCHEMBL9284109 | 0.96 | HIF1A (0.42) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Aziridine SCHEMBL6346107 | 0.96 | — | — | |
| SCHEMBL11114485 | 0.85 | — | — | |
| Piperazine SCHEMBL27908137 | 0.82 | — | — | |
| Piperidine SCHEMBL9525713 | 0.82 | — | — | |
| Piperidine SCHEMBL28384993 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| SCHEMBL8643744 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 | |
| Piperidine SCHEMBL28388670 | 0.82 | ALDH1A1 (0.60) | HIF1AMAPTPDE4AKDRCXCR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4336182-A | FIREPROOFING THERMOPLASTIC RESINS | MONTEDISON S.P.A. (IT) | 1982-06-22 | — | — | US | disclosed |