Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.48 |
| ▸ | DRD3 | P35462 | 2/20 | 0.48 |
| ▸ | HTR2B | P41595 | 4/20 | 0.45 |
| ▸ | ESR1 | P03372 | 1/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.38 |
| ▸ | LTB4R | Q15722 | 1/20 | 0.37 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.37 |
| ▸ | NOS1 | P29475 | 1/20 | 0.37 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.36 |
| ▸ | PRCP | P42785 | 1/20 | 0.36 |
| ▸ | HTR2A | P28223 | 2/20 | 0.36 |
| ▸ | HTR2C | P28335 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HCRTR1 | O43613 | 2/20 | 0.35 |
| ▸ | HCRTR2 | O43614 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11271245 | 0.98 | DRD2 (0.49) | DRD2DRD3HTR2BESR1ESR2 | |
| SCHEMBL14514593 | 0.95 | DRD2 (0.49) | DRD2DRD3HTR2BESR1ESR2 | |
| SCHEMBL29960407 | 0.79 | DRD2 (0.43) | DRD2DRD3HTR2BLTB4RLTB4R2 | |
| SCHEMBL30849006 | 0.79 | DRD2 (0.43) | DRD2DRD3HTR2BESR1ESR2 | |
| SCHEMBL11276001 | 0.78 | DRD2 (0.42) | DRD2DRD3HTR2BESR2LTB4R | |
| Hydrochloric Acid SCHEMBL29960656 | 0.78 | DRD2 (0.42) | DRD2DRD3HTR2BLTB4RLTB4R2 | |
| SCHEMBL13825739 | 0.77 | DRD2 (0.53) | DRD2DRD3HTR2BLTB4RLTB4R2 | |
| SCHEMBL8232785 | 0.77 | DRD2 (0.53) | DRD2DRD3HTR2BLTB4RLTB4R2 | |
| SCHEMBL8231800 | 0.77 | DRD2 (0.53) | DRD2DRD3HTR2BLTB4RLTB4R2 | |
| SCHEMBL8228508 | 0.77 | DRD2 (0.53) | DRD2DRD3HTR2BLTB4RLTB4R2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1448544-B1 | SUBSTITUTED BENZOPYRANS AS SELECTIVE ESTROGEN RECEPTOR-BETA AGONISTS | LILLY CO ELI (US) | 2007-05-16 | — | — | EP | disclosed |
| US-7217734-B2 | Substituted benzopyrans as selective estrogen receptor-beta agonists | ELI LILLY AND COMPANY (US) | 2007-05-15 | — | — | US | disclosed |
| EP-0004172-B1 | BENZOCYCLOHEPTAPYRANS, THEIR PREPARATION AND PHARMACEUTICAL FORMULATIONS CONTAINING THEM | ELI LILLY AND COMPANY (US) | 1982-04-07 | — | — | EP | disclosed |