Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 5/20 | 0.48 |
| ▸ | DPP4 | P27487 | 1/20 | 0.31 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.31 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11268004 | 0.83 | ACE (0.53) | ACEDPP4DPP8DPP9 | |
| SCHEMBL11271111 | 0.82 | ACE (0.68) | ACE | |
| SCHEMBL11305254 | 0.82 | ACE (0.68) | ACE | |
| SCHEMBL11269748 | 0.81 | ACE (0.45) | ACE | |
| SCHEMBL11266614 | 0.80 | ACE (0.50) | ACEDPP4DPP8DPP9 | |
| SCHEMBL11266618 | 0.80 | ACE (0.50) | ACEDPP4DPP8DPP9 | |
| SCHEMBL11263906 | 0.80 | ACE (0.50) | ACEDPP4DPP8DPP9 | |
| SCHEMBL11373489 | 0.78 | ACE (0.49) | ACE | |
| SCHEMBL10556618 | 0.78 | ACE (0.49) | ACE | |
| SCHEMBL11449625 | 0.77 | ACE (0.39) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4330548-A | HYPOTENSIVE AGENTS | E. R. SQUIBB & SONS, INC. (US) | 1982-05-18 | — | — | US | disclosed |
| US-4296113-A | FOR TREATING HYPERTENSION BY INHIBITING ANGIOTENSIN CONVERTING ENZYME | E. R. SQUIBB & SONS, INC. (US) | 1981-10-20 | — | — | US | disclosed |