Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | FAAH | O00519 | 14/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12322203 | 1.00 | CYP2D6 (0.51) | CYP2D6FAAHNPC1RAB9AHTT | |
| SCHEMBL6298554 | 0.86 | CYP2D6 (0.54) | CYP2D6FAAHHTTKDM4EL3MBTL1 | |
| SCHEMBL12322194 | 0.83 | HRH4 (0.54) | CYP2D6FAAHKMT2AKDM4EL3MBTL1 | |
| SCHEMBL11280431 | 0.83 | FAAH (0.49) | CYP2D6FAAHHTTMEN1KMT2A | |
| SCHEMBL12322218 | 0.83 | FAAH (0.49) | CYP2D6FAAHHTTKDM4EL3MBTL1 | |
| SCHEMBL3403909 | 0.80 | FAAH (0.55) | FAAH | |
| SCHEMBL13663284 | 0.80 | FAAH (0.55) | FAAH | |
| SCHEMBL11281707 | 0.79 | ESR1 (0.46) | CYP2D6NPC1RAB9AMEN1KMT2A | |
| SCHEMBL6300841 | 0.78 | KDM4E (0.50) | CYP2D6FAAHHTTKDM4EL3MBTL1 | |
| SCHEMBL3406721 | 0.77 | FAAH (0.68) | CYP2D6FAAH |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0004173-B1 | 2,3-DIHYDROIMIDAZO (1,2-C) PYRIMIDINES, THEIR PREPARATION, FORMULATIONS CONTAINING THEM AND THEIR USE AS PHARMACEUTICALS | ELI LILLY AND COMPANY (US) | 1982-09-22 | — | — | EP | disclosed |
| EP-0004173-A1 | 2,3-Dihydroimidazo (1,2-c) pyrimidines, their preparation, formulations containing them and their use as pharmaceuticals | ELI LILLY AND COMPANY (US) | 1979-09-19 | — | — | EP | disclosed |