Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 15/20 | 0.62 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.62 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.62 |
| ▸ | PDE4A | P27815 | 3/20 | 0.59 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.59 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.56 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16157002 | 0.97 | PDE3B (0.61) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL7296342 | 0.97 | PDE3B (0.61) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL10353457 | 0.92 | PDE3B (0.71) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11397791 | 0.87 | PDE3B (0.62) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11399727 | 0.86 | PDE3B (0.69) | PDE3BPDE3AGPR119PDE4APDE4B | |
| SCHEMBL11257256 | 0.86 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11393754 | 0.86 | PDE3B (0.61) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL11633346 | 0.85 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8342501 | 0.85 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL22317993 | 0.85 | PDE3B (0.64) | PDE3BPDE3APDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | claimed |
| EP-0010156-B1 | 6-ARYLPYRIDAZINE-3-ONES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND PROCESS FOR THEIR PREPARATION | MERCK PATENT GmbH (DE) | 1982-10-06 | — | — | EP | disclosed |
| US-4289774-A | Lipid lowering and anti-thrombotic 6-arylpyridazin-3-ones and a process for their preparation | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1981-09-15 | — | — | US | disclosed |
| EP-0010156-A1 | 6-Arylpyridazine-3-ones, pharmaceutical compositions containing them and process for their preparation | MERCK PATENT GmbH (DE) | 1980-04-30 | — | — | EP | disclosed |