Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | ATM | Q13315 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | GFER | P55789 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11272476 | 0.88 | POLB (0.44) | POLBDRD2HTR2AHTR2BATM | |
| SCHEMBL11274056 | 0.86 | POLB (0.64) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11447520 | 0.86 | POLB (0.60) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11053181 | 0.85 | POLB (0.62) | POLBDRD2HTR2AHTR2BPKM | |
| Hydrochloric Acid SCHEMBL11055122 | 0.85 | POLB (0.62) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL7440948 | 0.80 | POLB (0.71) | POLBATMSMN1; SMN2LMNAMAPT | |
| SCHEMBL11050215 | 0.79 | POLB (0.51) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11058762 | 0.78 | POLB (0.50) | POLBATMALDH1A1RAB9AL3MBTL1 | |
| SCHEMBL11057631 | 0.78 | POLB (0.53) | POLBDRD2HTR2AHTR2BPKM | |
| SCHEMBL11055498 | 0.78 | POLB (0.53) | POLBDRD2HTR2AHTR2BATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4304786-A | Amidinoureas | WILLIAM H. RORER, INC. (US) | 1981-12-08 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4147804-A | ANTIARRHYTHMIA AGENTS | WILLIAM H. RORER, INC. (US) | 1979-04-03 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |