Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EPHX2 | P34913 | 5/20 | 0.71 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | FAAH | O00519 | 2/20 | 0.56 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | CASP3 | P42574 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4104600 | 0.84 | MAPT (0.56) | EPHX2TDP1FAAHRAB9ANPC1 | |
| SCHEMBL9955776 | 0.84 | EPHX2 (0.62) | EPHX2TDP1FAAHEPHX1RAB9A | |
| SCHEMBL11555827 | 0.84 | EPHX2 (1.00) | EPHX2TDP1FAAHEPHX1RAB9A | |
| Hydrochloric Acid SCHEMBL4482069 | 0.83 | MAPT (0.54) | EPHX2TDP1FAAHRAB9ANPC1 | |
| SCHEMBL4104599 | 0.82 | EPHX2 (0.61) | EPHX2TDP1FAAHRAB9ANPC1 | |
| SCHEMBL11137428 | 0.82 | MAPT (0.71) | EPHX2TDP1RAB9ANPC1MAPT | |
| SCHEMBL29128694 | 0.81 | EPHX2 (0.75) | EPHX2TDP1FAAHEPHX1RAB9A | |
| SCHEMBL5643502 | 0.81 | EPHX2 (0.80) | EPHX2TDP1FAAHEPHX1RAB9A | |
| SCHEMBL169453 | 0.80 | EPHX2 (0.73) | EPHX2FAAHEPHX1RAB9ANPC1 | |
| SCHEMBL11058297 | 0.80 | EPHX2 (0.68) | EPHX2RAB9ANPC1MAPTKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |