Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 8/20 | 0.52 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127020 | 0.91 | BRAF (0.49) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL1127173 | 0.90 | NR1I2 (0.55) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL1127381 | 0.89 | NR1I2 (0.65) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL1870444 | 0.87 | BRAF (0.44) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL2193295 | 0.85 | BRAF (0.57) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL2193092 | 0.83 | BRAF (0.57) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL1127499 | 0.83 | BRAF (0.59) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL2190040 | 0.83 | BRAF (0.61) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL2193097 | 0.83 | BRAF (0.58) | BRAFNR1I2PLK4EPHB6RIPK2 | |
| SCHEMBL1127018 | 0.81 | BRAF (0.55) | BRAFNR1I2PLK4EPHB6RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |