Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1I2 | O75469 | 8/20 | 0.65 |
| ▸ | BRAF | P15056 | 18/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.41 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.41 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 1/20 | 0.41 |
| ▸ | ULK1 | O75385 | 1/20 | 0.41 |
| ▸ | ERN1 | O75460 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | KRAS | P01116 | 1/20 | 0.41 |
| ▸ | RAF1 | P04049 | 1/20 | 0.41 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | FYN | P06241 | 1/20 | 0.41 |
| ▸ | CDK1 | P06493 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
| ▸ | LYN | P07948 | 1/20 | 0.41 |
| ▸ | MET | P08581 | 1/20 | 0.41 |
| ▸ | HCK | P08631 | 1/20 | 0.41 |
| ▸ | FGR | P09769 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127181 | 0.91 | NR1I2 (0.53) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL1127379 | 0.90 | NR1I2 (0.67) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL1127175 | 0.89 | BRAF (0.53) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL1127251 | 0.88 | NR1I2 (0.49) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL1872195 | 0.87 | NR1I2 (0.48) | NR1I2BRAF | |
| SCHEMBL1127291 | 0.85 | NR1I2 (0.51) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL1127375 | 0.84 | BRAF (0.59) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL23458235 | 0.84 | BRAF (0.87) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL29721012 | 0.84 | BRAF (0.87) | NR1I2BRAFPLK4EPHB6RIPK2 | |
| SCHEMBL2195359 | 0.84 | BRAF (0.73) | NR1I2BRAFPLK4EPHB6RIPK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282636-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | GlaxoSmithKline LLC (US) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009137391-A2 | BENZENE SULFONAMIDE THIAZOLE AND OXAZOLE COMPOUNDS | SMITHKLINE BEECHAM CORPORATION (US) | 2009-11-12 | — | — | WO | disclosed |