Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.68 |
| ▸ | MELK | Q14680 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | ULK1 | O75385 | 1/20 | 0.68 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | PAK4 | O96013 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | FES | P07332 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | HCK | P08631 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31532631 | 1.00 | CHEK1 (0.68) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL20305897 | 0.89 | CHEK1 (0.69) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL12649363 | 0.88 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532687 | 0.88 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1127482 | 0.88 | CHEK1 (0.55) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1127833 | 0.87 | CHEK1 (0.51) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL5551102 | 0.86 | CHEK1 (0.57) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532532 | 0.86 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532628 | 0.86 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532650 | 0.86 | CHEK1 (0.79) | CHEK1MELKPLK4GAKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20110112144-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | ASTRAZENECA AB (SE) | 2011-05-12 | — | — | US | disclosed |
| EP-2305671-A1 | Thiophene and thiazole derivatives as CHK1 inhibitors | AstraZeneca AB (SE) | 2011-04-06 | — | — | EP | disclosed |
| EP-1732920-B1 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | ASTRAZENECA AB (SE) | 2011-03-09 | — | — | EP | disclosed |
| EP-2283012-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | AstraZeneca AB (SE) | 2011-02-16 | — | — | EP | disclosed |
| WO-2009133389-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | ASTRAZENECA AB (SE) | 2009-11-05 | — | — | WO | disclosed |
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | ASTRAZENECA AB (SE) | 2007-01-11 | — | — | US | disclosed |
| EP-1732920-A2 | THIOPHENE DERIVATIVES AS CHK 1 INHIBITORS | AstraZeneca AB (SE) | 2006-12-20 | — | — | EP | disclosed |
| WO-2005066163-A2 | THIOPHENE DERIVATIVES AS CHK 1 INIHIBITORS | ASTRAZENECA AB (SE) | 2005-07-21 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070010556-A1 | Thiophene derivatives as chk 1 inhibitors | CHEK1, CHKA, CHEK2 | CHEK1 1/4885MELK 259/4885PLK4 84/4885 |
| US-20110112144-A1 | METHODS OF PREPARING SUBSTITUTED HETEROCYCLES | HCCS, DPYD, TYMP | CHEK1 80/4885MELK 3335/4885PLK4 2749/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.