Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 18/20 | 0.68 |
| ▸ | MELK | Q14680 | 3/20 | 0.68 |
| ▸ | PLK4 | O00444 | 1/20 | 0.68 |
| ▸ | GAK | O14976 | 1/20 | 0.68 |
| ▸ | JAK2 | O60674 | 1/20 | 0.68 |
| ▸ | ULK1 | O75385 | 1/20 | 0.68 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.68 |
| ▸ | STK10 | O94804 | 1/20 | 0.68 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.68 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.68 |
| ▸ | PAK4 | O96013 | 1/20 | 0.68 |
| ▸ | ABL1 | P00519 | 1/20 | 0.68 |
| ▸ | EGFR | P00533 | 1/20 | 0.68 |
| ▸ | LCK | P06239 | 1/20 | 0.68 |
| ▸ | FYN | P06241 | 1/20 | 0.68 |
| ▸ | FES | P07332 | 1/20 | 0.68 |
| ▸ | YES1 | P07947 | 1/20 | 0.68 |
| ▸ | LYN | P07948 | 1/20 | 0.68 |
| ▸ | RET | P07949 | 1/20 | 0.68 |
| ▸ | HCK | P08631 | 1/20 | 0.68 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1127242 | 1.00 | CHEK1 (0.68) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL20305897 | 0.89 | CHEK1 (0.69) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL12649363 | 0.88 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532687 | 0.88 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1127482 | 0.88 | CHEK1 (0.55) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL1127833 | 0.87 | CHEK1 (0.51) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL5551102 | 0.86 | CHEK1 (0.57) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532532 | 0.86 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532628 | 0.86 | CHEK1 (0.62) | CHEK1MELKPLK4GAKJAK2 | |
| SCHEMBL31532650 | 0.86 | CHEK1 (0.79) | CHEK1MELKPLK4GAKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2025099238-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST) | Universität Duisburg-Essen (DE) | 2025-05-15 | — | — | WO | disclosed |
| EP-4552639-A1 | COMPOUNDS FOR USE IN THE TREATMENT OF GASTROINTESTINAL STROMAL TUMOR (GIST) | Universität Duisburg-Essen (DE) | 2025-05-14 | — | — | EP | disclosed |