Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.53 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | PDE5A | O76074 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | PTAFR | P25105 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | PDE1A | P54750 | 1/20 | 0.53 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.53 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
| ▸ | F11 | P03951 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6585256 | 0.94 | PDE3B (0.53) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL8860585 | 0.92 | PDE3B (0.52) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL6586939 | 0.89 | DRD2 (0.49) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL9626676 | 0.84 | PDE3B (0.53) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL7800216 | 0.84 | PDE3B (0.50) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL7802078 | 0.84 | PDE3B (0.50) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL7803109 | 0.83 | PDE3B (0.52) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL5474312 | 0.83 | PDE3B (0.55) | PDE3BPDE3AKDM4EMEN1PDE5A | |
| SCHEMBL1039407 | 0.83 | DRD2 (0.52) | DRD2DRD4DRD3ACHEMAOB | |
| SCHEMBL7802010 | 0.82 | PDE3B (0.51) | PDE3BPDE3AKDM4EMEN1PDE5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4259620-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | Cancer Research Technology Limited (GB) | 2023-10-18 | — | — | EP | disclosed |
| WO-2022123039-A1 | ALDEHYDE DEHYDROGENASE INHIBITORS AND THEIR THERAPEUTIC USE | CANCER RESEARCH TECHNOLOGY LIMITED (GB) | 2022-06-16 | — | — | WO | disclosed |
| EP-0003771-B1 | CARBOSTYRILE DERIVATIVES, THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | Dr. Karl Thomae GmbH (DE) | 1982-10-20 | — | — | EP | disclosed |
| US-4329347-A | Cardiotonic and antithrombotic sulfur-containing derivatives of carbostyril | BOEHRINGER INGELHEIM GMBH (DE) | 1982-05-11 | — | — | US | disclosed |