Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.51 |
| ▸ | GLA | P06280 | 1/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CDK4 | P11802 | 1/20 | 0.36 |
| ▸ | CCND1 | P24385 | 1/20 | 0.36 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.35 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.35 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.35 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.35 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 3/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8116649 | 1.00 | ALDH1A1 (0.51) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL5584578 | 0.78 | SNCA (0.44) | ALDH1A1GLATDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL5584237 | 0.78 | SNCA (0.44) | ALDH1A1GLATDP1CYP3A4SMN1; SMN2 | |
| SCHEMBL5585110 | 0.77 | ALDH1A1 (0.56) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL8156163 | 0.76 | ALDH1A1 (0.61) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL8156166 | 0.76 | ALDH1A1 (0.61) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL8118307 | 0.75 | ALDH1A1 (0.52) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL8118300 | 0.75 | ALDH1A1 (0.52) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL5584748 | 0.74 | ALDH1A1 (0.55) | ALDH1A1GLATDP1CDK4CCND1 | |
| SCHEMBL8120656 | 0.74 | ALDH1A1 (0.51) | ALDH1A1GLATDP1CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4353917-A | HYPOTENSIVE, ANTIARRHYTHMIA, ANGINA RECTORIS | BASF AKTIENGESELLSCHAFT (DE) | 1982-10-12 | — | — | US | disclosed |
| US-4305950-A | FOR TREATMENT OF CORONARY DISEASES, OF HYPERTONIA AND OF CARDIAC ARRHYTHMIAS | BASF AKTIENGESELLSCHAFT (DE) | 1981-12-15 | — | — | US | disclosed |
| EP-0006971-B1 | AMINO DERIVATIVES OF 2-METHYL-5-(2-HYDROXYSTYRYL)-1,3,4-THIADIAZOLES, PROCESS FOR THEIR PREPARATION AND THERAPEUTICAL COMPOSITIONS CONTAINING THEM | BASF Aktiengesellschaft (DE) | 1981-12-02 | — | — | EP | disclosed |
| EP-0027977-A1 | Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazole, process for their preparation and compositions containing them | BASF Aktiengesellschaft (DE) | 1981-05-06 | — | — | EP | disclosed |
| US-4263430-A | BETA BLOCKER, FOR CARDIOVASCULAR DISEASE | BASF AKTIENGESELLSCHAFT (DE) | 1981-04-21 | — | — | US | disclosed |
| US-4237278-A | CARDIOVASCULAR DISORDERS | BASF AKTIENGESELLSCHAFT (DE) | 1980-12-02 | — | — | US | disclosed |
| EP-0006971-A1 | Amino derivatives of 2-methyl-5-(2-hydroxystyryl)-1,3,4-thiadiazoles, process for their preparation and therapeutical compositions containing them | BASF Aktiengesellschaft (DE) | 1980-01-23 | — | — | EP | disclosed |
| EP-0005174-A1 | 2-Methyl-5-(2-hydroxystyryl)-1.3.4-thiadiazole and its preparation | BASF Aktiengesellschaft (DE) | 1979-11-14 | — | — | EP | disclosed |