SCHEMBL11273699

SCHEMBL11273699

CC1=C(C#C/C(C)=C/CO)C(C)(C)CCC1=O

nearest known ligand 0.36

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
MAPT P10636 1/20 0.36
ALOX15 P16050 1/20 0.36
TRPA1 O75762 1/20 0.31
FFAR1 O14842 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11273701 1.00 MAPT (0.36) MAPTALOX15TRPA1FFAR1
SCHEMBL11517151 0.88 MAPT (0.36) MAPTALOX15TRPA1
SCHEMBL11432417 0.86 FFAR1 (0.32) FFAR1
Bromide SCHEMBL11517153 0.84 MAPT (0.39) MAPTALOX15TRPA1
Bromide SCHEMBL11437682 0.78 MAPT (0.32) MAPTALOX15
SCHEMBL10748261 0.77 ALDH1A1 (0.43) MAPTALOX15FFAR1
SCHEMBL10748262 0.77 ALDH1A1 (0.43) MAPTALOX15FFAR1
SCHEMBL3136770 0.76 MAPT (0.39) MAPTFFAR1
SCHEMBL3136775 0.76 MAPT (0.39) MAPTFFAR1
SCHEMBL3131652 0.75

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4111992-A SUBSTITUTED CYCLOHEXENONES HOFFMANN-LA ROCHE INC. (US) 1978-09-05 US claimed
US-4323711-A Process for producing cyclohexenes HOFFMANN-LA ROCHE INC. (US) 1982-04-06 US disclosed
US-4323711-A Process for producing cyclohexenes HOFFMANN-LA ROCHE INC. (US) 1982-04-06 US disclosed
US-4227022-A CHEMICAL INTERMEDIATES FOR FOOD COLORING AGENTS; CANTHAXANTHIN HOFFMANN-LA ROCHE INC. (US) 1980-10-07 US disclosed
US-4157345-A INTERMEDIATE IN SYNTHESIS OF CANTHAXANTHIN HOFFMANN-LA ROCHE INC. (US) 1979-06-05 US disclosed
US-4153805-A REACTING 1-(1-HYDROXY-2,6,6-TRIMETHYL-CYCLOHEX-2-EN-1-YL)-3-ALKOXY-3-METHYL-PENT-4-EN-1-YNE WITH AN ALKANOIC ACID HOFFMANN-LA ROCHE INC. (US) 1979-05-08 US disclosed
US-4111992-A SUBSTITUTED CYCLOHEXENONES HOFFMANN-LA ROCHE INC. (US) 1978-09-05 US disclosed
US-4088689-A INTERMEDIATES FOR CANTHAXANTHIN HOFFMANN-LA ROCHE INC. (US) 1978-05-09 US disclosed
US-4045476-A CANTHAXANTHIN INTERMEDIATES HOFFMANN-LA ROCHE INC. (US) 1977-08-30 US disclosed
US-4025564-A FOOD COLORING AGENTS HOFFMANN-LA ROCHE INC. (US) 1977-05-24 US disclosed
US-4000198-A INTERMEDIATE FOR CANTHAXANTHIN HOFFMANN-LA ROCHE INC. (US) 1976-12-28 US disclosed