Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 8/20 | 0.36 |
| ▸ | MAPT | P10636 | 3/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | PDE1A | P54750 | 3/20 | 0.33 |
| ▸ | PDE1B | Q01064 | 3/20 | 0.33 |
| ▸ | PDE1C | Q14123 | 3/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | PKM | P14618 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11273505 | 1.00 | PDE5A (0.36) | PDE5AMAPTMAPK14TSHRMAPK1 | |
| SCHEMBL11261101 | 0.89 | MAPT (0.37) | PDE5AMAPTMAPK14TSHRMAPK1 | |
| SCHEMBL11261107 | 0.89 | MAPT (0.37) | PDE5AMAPTMAPK14TSHRMAPK1 | |
| SCHEMBL9075797 | 0.86 | PDE5A (0.37) | PDE5AMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL9075964 | 0.85 | PDE5A (0.36) | PDE5AMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL10425304 | 0.82 | PDE5A (0.37) | PDE5AMAPTMAPK14TSHRMAPK1 | |
| SCHEMBL11005943 | 0.81 | MAPT (0.35) | PDE5AMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL11264705 | 0.80 | PI4KB (0.38) | PDE5AMAPTTSHRMAPK1SMN1; SMN2 | |
| SCHEMBL11564970 | 0.80 | MAPK1 (0.52) | PDE5AMAPK14MAPK1SMN1; SMN2NPC1 | |
| SCHEMBL9076346 | 0.80 | MAPT (0.35) | PDE5AMAPTTSHRMAPK1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4313945-A | 7-Thiazolyl-acetamido-cephem derivatives with terminal aminocarboxylic acid grouping | CIBA-GEIGY CORPORATION (US) | 1982-02-02 | — | — | US | disclosed |