Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2D6 | P10635 | 2/20 | 0.54 |
| ▸ | ADRA1A | P35348 | 3/20 | 0.53 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.53 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.50 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.50 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.50 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | ACHE | P22303 | 1/20 | 0.47 |
| ▸ | SCN1A | P35498 | 1/20 | 0.46 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.46 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA7 | P43166 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264165 | 0.88 | CYP2D6 (0.43) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL19389253 | 0.85 | CYP2D6 (0.56) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL11253139 | 0.83 | ADRA1A (0.57) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL11251015 | 0.81 | CYP2D6 (0.59) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL19121206 | 0.81 | CYP2D6 (0.51) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL11363489 | 0.80 | CYP2D6 (0.50) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL20350303 | 0.80 | CYP2D6 (0.50) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL19121531 | 0.80 | CYP2D6 (0.50) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL4980642 | 0.79 | ADRA1A (0.60) | CYP2D6ADRA1AADRA2AADRB2ADRB1 | |
| SCHEMBL11424531 | 0.79 | ADRA1A (0.70) | CYP2D6ADRA1AADRA2AADRB2ADRB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0009386-B1 | 2,10-DISUBSTITUTED DIBENZO(B,D)PYRANS AND BENZO(C)QUINOLINES AND PHARMACEUTICAL COMPOSITIONS THEREOF | PFIZER INC. (US) | 1982-11-17 | — | — | EP | disclosed |
| US-4206225-A | ANALGESICS | PFIZER INC. (US) | 1980-06-03 | — | — | US | disclosed |
| EP-0009386-A1 | 2,10-Disubstituted dibenzo(b,d)pyrans and benzo(c)quinolines and pharmaceutical compositions thereof | PFIZER INC. (US) | 1980-04-02 | — | — | EP | disclosed |