Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACE | P12821 | 12/20 | 0.54 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10943437 | 1.00 | ACE (0.54) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL11281944 | 1.00 | ACE (0.54) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL11281946 | 1.00 | ACE (0.54) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL10940814 | 0.90 | ACE (0.59) | ACE | |
| SCHEMBL11271666 | 0.90 | ACE (0.59) | ACE | |
| SCHEMBL11271671 | 0.90 | ACE (0.59) | ACE | |
| SCHEMBL11271681 | 0.90 | ACE (0.59) | ACE | |
| SCHEMBL11382738 | 0.85 | ACE (0.63) | ACELMNAMEN1KMT2AUSP2 | |
| SCHEMBL11275565 | 0.81 | ACE (0.52) | ACELMNAMEN1KMT2A | |
| SCHEMBL10943539 | 0.78 | ACE (0.46) | ACE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0059966-A1 | Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | claimed |
| EP-0059966-A1 | Substituted thiazolidine carboxylic acid analogs and derivatives as antihypertensives | MERCK & CO. INC. (US) | 1982-09-15 | — | — | EP | disclosed |