SCHEMBL11275265

SCHEMBL11275265

CCOC(=O)C(=CC#N)c1ccccc1

nearest known ligand 0.50

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.50
MAPT P10636 4/20 0.50
MEN1 O00255 3/20 0.49
KMT2A Q03164 3/20 0.49
SMN1; SMN2 Q16637 4/20 0.47
TDP1 Q9NUW8 3/20 0.44
L3MBTL1 Q9Y468 2/20 0.44
LMNA P02545 2/20 0.44
GAA P10253 3/20 0.43
DHODH Q02127 2/20 0.43
TP53 P04637 1/20 0.43
NPC1 O15118 2/20 0.43
ATM Q13315 1/20 0.42
KDM4E B2RXH2 1/20 0.42
RAB9A P51151 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
POLB P06746 1/20 0.42
CYP1A2 P05177 1/20 0.42
CYP2C19 P33261 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11275268 1.00 ALDH1A1 (0.50) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL17793352 0.85 SMN1; SMN2 (0.46) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL17787001 0.85 SMN1; SMN2 (0.46) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL11762855 0.83 PDE4A (0.53) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL28550892 0.83 ALDH1A1 (0.48) ALDH1A1MAPTSMN1; SMN2TDP1LMNA
SCHEMBL11762839 0.83 PDE4A (0.53) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL28619132 0.82 ALDH1A1 (0.57) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL1336621 0.82 ALDH1A1 (0.57) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL27934857 0.82 ALDH1A1 (0.57) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2
SCHEMBL15084647 0.80 ALDH1A1 (0.56) ALDH1A1MAPTMEN1KMT2ASMN1; SMN2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20220160645-A1 NANOPARTICLES COMPRISING COPOLYMERIC OR HOMOPOLYMERIC COMPOUNDS WHICH COMPRISE CYANOACRYLATE SUBUNITS SINTEF TTO AS (NO) 2022-05-26 US disclosed
EP-3952836-A1 NANOPARTICLES COMPRISING COPOLYMERIC OR HOMOPOLYMERIC COMPOUNDS WHICH COMPRISE CYANOACRYLATE SUBUNITS SINTEF TTO AS (NO) 2022-02-16 EP disclosed
WO-2020207655-A1 NANOPARTICLES COMPRISING COPOLYMERIC OR HOMOPOLYMERIC COMPOUNDS WHICH COMPRISE CYANOACRYLATE SUBUNITS SINTEF TTO AS (NO) 2020-10-15 WO disclosed
EP-2852646-B1 AN ARTICLE COMPRISING A FILM ON A CARRIER OR RELEASE SUBSTRATE Henkel IP & Holding GmbH (DE) 2017-07-12 EP disclosed
US-20150107761-A1 ARTICLE COMPRISING A FILM ON A CARRIER OR RELEASE SUBSTRATE HENKEL AG & CO. KGAA (DE) 2015-04-23 US disclosed
EP-2852646-A1 AN ARTICLE COMPRISING A FILM ON A CARRIER OR RELEASE SUBSTRATE Henkel IP & Holding GmbH (DE) 2015-04-01 EP disclosed
WO-2013174776-A1 AN ARTICLE COMPRISING A FILM ON A CARRIER OR RELEASE SUBSTRATE HENKEL AG & CO. KGAA (DE) 2013-11-28 WO disclosed
US-4335054-A Process for the preparation of alkenylbenzenecarboxylic acid derivatives and alkenylnaphthalenecarboxylic acid derivatives CIBA-GEIGY CORPORATION (US) 1982-06-15 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20220160645-A1 NANOPARTICLES COMPRISING COPOLYMERIC OR HOMOPOLYMERIC COMPOUNDS WHICH COMPRISE CYANOACRYLATE SUBUNITS CD47, PSMA2, C3AR1 ALDH1A1 1403/4885MAPT 1919/4885MEN1 468/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.