Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | PGR | P06401 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL699259 | 0.83 | SMN1; SMN2 (0.50) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL11128386 | 0.81 | ESR1 (0.43) | ALDH1A1CYP3A4KDM4EMAPTMEN1 | |
| SCHEMBL11275400 | 0.80 | POLB (0.42) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL698901 | 0.75 | — | — | |
| SCHEMBL1816541 | 0.72 | POLB (0.52) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL532346 | 0.72 | POLB (0.56) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL28024707 | 0.71 | POLB (0.56) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL11306411 | 0.71 | POLB (0.45) | POLBALDH1A1TP53CYP3A4TSHR | |
| SCHEMBL18156889 | 0.70 | POLB (0.61) | POLBALDH1A1TP53CYP3A4TSHR | |
| Hydrochloric Acid SCHEMBL19857169 | 0.70 | POLB (0.61) | POLBALDH1A1TP53CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4322434-A | N-Substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1982-03-30 | — | — | US | disclosed |
| US-4267193-A | N-substituted-4-(polyfluoro-2-hydroxy-2-propyl)anilines and compounds related thereto | SCHERING CORPORATION (US) | 1981-05-12 | — | — | US | disclosed |