SCHEMBL11276072

SCHEMBL11276072

CCOC(=O)C(C)(C)C(=O)C(Br)Oc1ccc(C#N)cc1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH2 P25021 1/20 0.40
HRH1 P35367 1/20 0.40
HRH3 Q9Y5N1 1/20 0.40
CNR2 P34972 1/20 0.38
MMP2 P08253 5/20 0.38
MMP3 P08254 3/20 0.38
ALDH1A1 P00352 1/20 0.38
MAPT P10636 1/20 0.38
ABCB11 O95342 1/20 0.37
CYP1A2 P05177 1/20 0.37
CYP3A4 P08684 1/20 0.37
TSHR P16473 1/20 0.37
HTR2A P28223 1/20 0.37
PMP22 Q01453 1/20 0.37
PPARA Q07869 1/20 0.37
MGLL Q99685 2/20 0.37
RAB9A P51151 1/20 0.37
GAA P10253 1/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CYP11B1 P15538 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL11271227 0.84 ALDH1A1 (0.41) HRH2HRH1ALDH1A1MAPTABCB11
SCHEMBL11271870 0.84 ALDH1A1 (0.43) ALDH1A1MAPTABCB11CYP1A2CYP3A4
SCHEMBL11272661 0.83 PPARA (0.56) ALDH1A1MAPTABCB11CYP1A2CYP3A4
SCHEMBL11285398 0.83 CYP1A2 (0.40) ALDH1A1MAPTABCB11CYP1A2CYP3A4
SCHEMBL11266219 0.82 MAPT (0.47) MAPTCYP1A2PPARARAB9AGAA
SCHEMBL11277557 0.81 PPARA (0.53) HRH2HRH1CNR2ALDH1A1MAPT
SCHEMBL11396368 0.81 MAPT (0.40) MMP2MMP3ALDH1A1MAPTPPARA
SCHEMBL11271624 0.81 SMN1; SMN2 (0.47) MAPTABCB11CYP1A2CYP3A4TSHR
SCHEMBL11539219 0.80 MAPT (0.41) MMP2MMP3ALDH1A1MAPTPPARA
SCHEMBL11270059 0.80 PPARA (0.52) ALDH1A1MAPTABCB11CYP1A2CYP3A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-4331674-A Combating fungi with 4-phenoxy-4-(azolyl-1-yl)-butanoic acid derivatives BAYER AKTIENGESELLSCHAFT (DE) 1982-05-25 US disclosed