Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 10/20 | 0.60 |
| ▸ | PPIA | P62937 | 4/20 | 0.49 |
| ▸ | F2 | P00734 | 3/20 | 0.48 |
| ▸ | F10 | P00742 | 3/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 3/20 | 0.48 |
| ▸ | F7 | P08709 | 3/20 | 0.48 |
| ▸ | PRSS2 | P07478 | 2/20 | 0.48 |
| ▸ | F3 | P13726 | 2/20 | 0.48 |
| ▸ | PRSS3 | P35030 | 2/20 | 0.48 |
| ▸ | CTSV | O60911 | 1/20 | 0.47 |
| ▸ | CTSL | P07711 | 1/20 | 0.47 |
| ▸ | MRGPRX1 | Q96LB2 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7167350 | 0.88 | PPIA (0.47) | C5AR1PPIA | |
| SCHEMBL11265836 | 0.87 | C5AR1 (0.63) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11595438 | 0.87 | C5AR1 (0.69) | C5AR1F2F10PRSS1F7 | |
| Hydrochloric Acid SCHEMBL11596870 | 0.85 | C5AR1 (0.67) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11264325 | 0.85 | C5AR1 (0.60) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11141513 | 0.85 | C5AR1 (0.60) | C5AR1F2F10PRSS1F7 | |
| Hydrochloric Acid SCHEMBL11258213 | 0.84 | C5AR1 (0.59) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11050131 | 0.82 | MAPT (0.55) | F2F10PRSS1F7 | |
| SCHEMBL11253653 | 0.81 | C5AR1 (0.55) | C5AR1PPIAF2F10PRSS1 | |
| SCHEMBL11254177 | 0.78 | C5AR1 (0.50) | C5AR1F2F10PRSS1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |