Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C5AR1 | P21730 | 14/20 | 0.63 |
| ▸ | F2 | P00734 | 2/20 | 0.48 |
| ▸ | F10 | P00742 | 2/20 | 0.48 |
| ▸ | PRSS1 | P07477 | 2/20 | 0.48 |
| ▸ | F7 | P08709 | 2/20 | 0.48 |
| ▸ | MRGPRX1 | Q96LB2 | 2/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.45 |
| ▸ | F3 | P13726 | 1/20 | 0.45 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | UBE2N | P61088 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11264325 | 0.90 | C5AR1 (0.60) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11595438 | 0.89 | C5AR1 (0.69) | C5AR1F2F10PRSS1F7 | |
| Hydrochloric Acid SCHEMBL11258213 | 0.89 | C5AR1 (0.59) | C5AR1F2F10PRSS1F7 | |
| Hydrochloric Acid SCHEMBL11596870 | 0.88 | C5AR1 (0.67) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11276150 | 0.87 | C5AR1 (0.60) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11141513 | 0.87 | C5AR1 (0.60) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11280329 | 0.87 | C5AR1 (0.47) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11283867 | 0.86 | C5AR1 (0.58) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11596780 | 0.84 | C5AR1 (0.62) | C5AR1F2F10PRSS1F7 | |
| SCHEMBL11279359 | 0.84 | C5AR1 (0.56) | C5AR1F2F10PRSS1F7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4326075-A | ANTIDIARRHEA AGENTS | WILLIAM H. RORER, INC. (US) | 1982-04-20 | — | — | US | disclosed |
| US-4203920-A | ANTIDIARRHEAL | WILLIAM H. RORER, INC. (US) | 1980-05-20 | — | — | US | disclosed |
| US-4060635-A | Amidinoureas for treating diarrhea | WILLIAM H. RORER, INC. (US) | 1977-11-29 | — | — | US | disclosed |